What is delta-8-tetrahydrocannabinol (∆8 THC)?

Tetrahydrocannabinol (THC) is the primary psychoactive compound found in the cannabis plant. Delta-8 THC (∆8 THC) is a minor analog of Delta-9 THC (∆9 THC) and has gained popularity in the cannabis industry. This blog post aims to provide a scientific overview of Delta-8 THC, including its effects, differences from Delta-9 THC, and potential uses.

What is Delta-8 THC?

Delta-8 THC, or D8 THC or ∆8 THC, is a psychoactive cannabinoid that is a minor analog of Delta-9 THC (∆9 THC). Its chemical structure is similar to that of Delta-9 THC, but it has some differences in its effects. Delta-8 THC has a double bond on the eighth carbon atom of its molecular chain, while Delta-9 THC has a double bond on the ninth carbon atom.

Studies have shown that Delta-8 THC has a lower psychotropic potency than Delta-9 THC, suggesting that it may produce a milder and less anxiety-inducing high. However, more research is needed to determine the full extent of these differences, as the effects of Delta-8 THC can vary depending on the dose, route of administration, and individual differences.

How is Delta-8 THC Synthesized?

Delta 8 THC, or delta-8-tetrahydrocannabinol, is a psychoactive cannabinoid that is a structural analog of Delta 9 THC, the more well-known psychoactive cannabinoid found in cannabis.

Delta 8 THC is created by converting CBD (cannabidiol) or Delta 9 THC into Delta 8 THC through a chemical reaction. The conversion can be achieved through various methods, including isomerization, distillation, and chemical synthesis.

The conversion of CBD into Δ8-THC is a complex process that involves several steps. One common method is the isomerization of CBD using a Lewis acid catalyst, such as boron trifluoride (BF3) or hydrochloric acid (HCl).

Isomerization involves changing the molecular structure of a compound without changing its chemical formula. In this process, CBD is heated with an acid catalyst to form Delta 9 THC, which is then converted into Delta 8 THC by exposing it to a reducing agent like hydrogen gas.

The reaction takes place under acidic conditions, in which CBD is protonated, followed by the formation of a carbocation intermediate. This intermediate rearranges to form Δ8-THC, which can then be isolated and purified.

Distillation involves isolating and purifying the compound from a cannabis extract. In this process, Delta 8 THC is separated from other cannabinoids using fractional distillation, which takes advantage of the differences in boiling points between different compounds.

Chemical synthesis is another method of creating Delta 8 THC, which involves combining different chemicals in a laboratory to create the compound. This method is less common due to the high cost and complexity of the process.

It’s worth noting that the conversion of CBD to Δ8-THC is not an entirely efficient process, and a significant amount of byproducts, such as Δ9-THC, can also be formed. Therefore, it’s crucial for manufacturers to optimize their procedures to minimize the formation of unwanted compounds.

How Does Delta-8 THC Work?

Like other cannabinoids, Delta-8 THC works by binding to the cannabinoid receptors in the brain and body. It has a high affinity for the CB1 receptor, which is responsible for the psychoactive effects of THC. However, Delta-8 THC also has an affinity for the CB2 receptor, which is involved in the immune system and inflammation.

The binding of Delta-8 THC to these receptors can produce a variety of effects, including euphoria, relaxation, pain relief, and appetite stimulation. However, more research is needed to fully understand the mechanisms of action of Delta-8 THC.

Will Delta-8 THC Get Me high?

Yes, Delta-8 THC is a psychoactive compound that produces a high similar to Delta-9 THC. The intensity and duration of the high can vary depending on the person, the dose, and the method of consumption.

Some people prefer Delta-8 THC to Delta-9 THC because they find it to be less anxious and more clear-headed. However, it is important to note that Delta-8 THC will still produce psychoactive effects and should be used responsibly.

Will I Pass a Drug Test if I Use Delta-8 THC?

No, but maybe. Most drug tests are designed to detect Delta-9 THC, as it is the most common form of THC found in cannabis. However, some drug tests may also detect Delta-8 THC, as it is a psychoactive cannabinoid. If you are concerned about passing a drug test, it is best to avoid all forms of THC.

Recreational Uses for Delta-8 THC

Delta-8 THC is primarily used for recreational purposes, as it produces a high similar to Delta-9 THC. Some people prefer Delta-8 THC to Delta-9 THC because they find it to be less anxious and more clear-headed. However, more research is needed to fully understand the differences between the two compounds.

Delta-8 THC can be found in a variety of products, including:

  1. Delta-8 THC edibles: These are food products that contain Delta-8 THC, such as gummies, chocolates, and baked goods.
  2. Delta-8 THC tinctures: These are liquid products that are taken sublingually (under the tongue) and contain Delta 8 THC.
  3. Delta-8 THC cartridges: These are vape cartridges that contain Delta-8 THC oil and can be used with a compatible vape pen.
  4. Delta-8 THC concentrates: These are highly concentrated forms of Delta-8 THC that are typically used with a dab rig.

It is important to note that the quality and purity of Delta-8 THC products can vary, and some products may contain contaminants or other substances. It is essential to purchase Delta-8 THC products from a reputable source and to follow the recommended dosage and administration instructions.

Medical Uses for Delta-8 THC

Although Delta-8 THC is primarily used for recreational purposes, it may also have potential medical uses. Some studies have shown that Delta-8 THC may have similar therapeutic effects to Delta-9 THC, including:

  1. Pain relief: Delta-8 THC has been shown to have pain-relieving properties in animal studies. One study found that Delta-8 THC was effective in reducing pain and inflammation in rats with corneal injury.
  2. Appetite stimulation: Delta-8 THC has been shown to increase appetite in animal studies. One study found that Delta-8 THC increased food intake in mice more effectively than Delta-9 THC.
  3. Antiemetic effects: Delta-8 THC has been shown to have antiemetic (anti-nausea and vomiting) effects in animal studies. One study found that Delta-8 THC was effective in reducing nausea and vomiting in pediatric cancer patients.

However, more research is needed to fully understand the potential medical uses of Delta-8 THC. It is also important to note that Delta-8 THC is a Schedule I controlled substance in the United States, and its use and possession are illegal under federal law.

Delta 8 THC Prodcuts

Common Products that Include Delta-8 THC

Delta-8 THC products are becoming increasingly popular in the cannabis industry, and many companies are now offering Delta-8 THC products. Some common products that include Delta-8 THC include:

  1. Delta-8 THC gummies: These are edible products that contain Delta-8 THC and are similar to traditional cannabis edibles.
  2. Delta-8 THC vape cartridges: These are cartridges that contain Delta-8 THC oil and can be used with a compatible vape pen.
  3. Delta-8 THC tinctures: These are liquid products that are taken sublingually (under the tongue) and contain Delta-8 THC.
  4. Delta-8 THC concentrates: These are highly concentrated forms of Delta-8 THC that are typically used with a dab rig.

It is important to note that the quality and purity of Delta-8 THC products can vary, and some products may contain contaminants or other substances. It is essential to purchase Delta-8 THC products from a reputable source and to follow the recommended dosage and administration instructions.

Who Should Try Delta-8 THC and Why?

Delta-8 THC is a psychoactive compound that produces a high similar to Delta-9 THC. It is primarily used for recreational purposes, but it may also have potential medical uses. It is important to note that Delta-8 THC is a Schedule I controlled substance in the United States, and its use and possession are illegal under federal law.

If you are interested in trying Delta-8 THC, it is essential to do so responsibly and to follow the recommended dosage and administration instructions. It is also important to purchase Delta-8 THC products from a reputable source and to avoid products that may contain contaminants or other substances.

Kush.com Certified Products

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By doing so, the Kush.com Certified program provides consumers with safer choices when selecting hemp and cannabis products. See the full product lineup here.

In Conclusion

Delta-8 THC is a relatively new compound in the cannabis industry that has gained popularity for its potential recreational and medical uses. Although it produces a high similar to Delta-9 THC, it may have some differences in its effects and may be less potent. However, more research is needed to fully understand the potential benefits and risks of Delta-8 THC.

It is essential to use Delta-8 THC responsibly and to follow the recommended dosage and administration instructions. It is also important to purchase Delta-8 THC products from a reputable source and to avoid products that may contain contaminants or other substances. As with any substance, it is crucial to be aware of the potential risks and to make informed decisions about its use.


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